What is Amino Acid Carnitines
In this health video you will learn what amino acid carnitines do when they are made inside your body.
Tom Audette: Ken, in the last few years Sigma-Tau has been in the forefront of
developing some new L-carnitine molecules. You refer to them as amino
carnitines. Could you tell us a little bit about that? And particularly the one
that is called Acetyl L-Carnitine Arginine.
Dr. Ken Hassen: Sure. Actually for those that are interested in getting more information
immediately, they can go to the websites devoted to the,
www.aminocarnitines.com and www.modernarteries.com. But essentially
this is the next stage of carnitine development. I mean this is a renovation
of the molecule. What we found is, is that carnitine itself is manufactured
from amino acids such as lysine and methionine. Part of our research has
been devoted to experimenting with carnitine actually bonded molecularly
to certain amino acids. And the concept would be that…to mix them
together would seem to be beneficial, but there’s no way of assuring that
there would be a uniform mix when it goes from the drum, into the
capsule, into the tablet, into the bottle, into the person. So what we did was
we molecularly bonded carnitine with specific amino acids based on what
the literature shows might prove to be beneficial from a metabolic
We call these groups the amino carnitines because they’re carnitines that
are structurally bonded to amino acids. The benefit is that each molecule
of any of the amino carnitines gives a specific amount of amino acid as
well as a specific amount of a particular form of carnitine, which allows
for regeneration carnitine to occur and also to get that effect, kind of like
uniform metering. The principle ones are carnitine arginate or
ArginoCarn. It’s a mix of acetyl L-carnitine and arginine. Now arginine
has been shown to have properties that support nerve function. Also, in
male sexual health arginine is very important and acetyl L-carnitine too is
important in nerve functioning and male sexual health, so there’s a very
strong component there.
We have some research interventions that are undergoing now that are
looking at ArginoCarn for how insulin uptake is affected from a dietary
standpoint. Another intervention that we’re getting underway for nerve
function, for carpel tunnel syndrome. Not as a treatment, but just as a
dietary assist to see if there’s any effect from a dietary standpoint.
Tom Audette: As you were talking specifically about the amino carnitine, that is the
acetyl L-carnitine arginate. I think it’s important that you mentioned
earlier that this is a new molecule, that you’re not just mixing these two
things together, but in fact you’ve created a new molecule in the process
of doing this.
Dr. Ken Hassen: Exactly right. One of the challenges of getting vitamins into the capsule or
tablet is to make sure that you have good mixing in-between. In other
words, if you have two separate ingredients it’s possible to get them into
the tablet so that each tablet has the same exact amount. But it’s much
more predictable, much more simpler if you have a bonded molecule. So
what we’ve actually done is bonded the amino acid to the carnitine. This
allows us not only to assure that there is a more stricter metering of the
product as it enters the biochemical pathways, but it also allows for us to
plan our research protocols more effectively because we know that we
don’t have to deal with problems where there isn’t a right, adequate
mix…that the mix is off or anything…that there is content uniformity in
the product, which allows for more stricter adherence to research
It’s been very exciting and now we’re into our fourth year and now it’s
slowly taking over the category for acetyl carnitine. ArginoCarn is
becoming the next version of acetyl carnitine of choice in the marketplace.
Tom Audette: Sigma-Tau holds patents on the process?
Dr. Ken Hassen: Yes, we have patents on it that…the product is…and this is important
because we need to assure that we have GMPs. The product, especially
when it was new…it’s no longer new…they’ve been out now four years,
but that we have a very strict process for pharmaceutical quality batch
production and that it’s very important that we maintain those standards.
Tom Audette: Okay, thank you Ken.
What is Amino Acid Carnitines
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